Christian view Essay Example | Topics and Well Written Essays - 750 words

Christian view - Essay Example The process of creation of the world is described in the Book of Genesis. It features main elements, like Days of Creation, as well as aftermath such as life of Adam and Eve. However, this text also has some important implications for the contemporary Christians. Thus, it was argued that â€Å"the notion that humanity has the â€Å"responsibility† to exercise care over the earth from its higher position often results not so much in â€Å"stewardship† that guards the earth as in domination and exploitation† (Chopp and Taylor 6). Indeed, other than being the most perfect creature, a human being is a creature with â€Å"responsibility†. Some might go as far as saying that the concept of the Original Sin should be focused on exclusively on eating the fruits of the forbidden tree, but rather on abandoning the above mentioned â€Å"responsibility†.Creation and the TrinityAs it often happens in the Bible some earlier parts of it are related to the later on e. In other words, the Bible is a set of interconnected books, though they were written in different times. That is why some scholars point that there is a strong relationship between Genesis which is the first book of the Bible and the doctrine of Trinity which is something that appeared much later. For example, it is explained that â€Å"Creator, Redeemer, and Sustainer [the Three Persons of the Holy Trinity]†¦ these terms refer †¦ to God’s relations with the creation† (Hanson 42). In other words, one of the characteristic features of God the Father was the creation of the world.

Solid Dispersion System in Drug Delivery

Solid Dispersion System in Drug Delivery The oral route remains the preferred route of drug administration due to its convenience, good patient compliance and low medicine production costs. In order for a drug to be absorbed into the systemic circulation following oral administration, the drug must be dissolved in the gastric fluids. The active pharmaceutical ingredient in a solid dosage form must undergo dissolution before it is available for absorption from the gastrointestinal tract.1 Currently, approximately 40% of the marketed immediate release (IR) oral drugs are categorized as practically insoluble ( 1.1 Biopharmaceutics classification system The Biopharmaceutical Classification System (BCS) was introduced in the mid-1990s to classify the drug substances with respect to their aqueous solubility and membrane permeability. BCS is a useful tool for decision-making in formulation development from a biopharmaceutical point of view. Solubility improvement strategies are required for Class II and Class IV drugs. 1.2 Approaches to improve the solubility or to increase the available surface area for dissolution Physical modifications Particle size Micronization Nanosuspensions Modifications of the crystal habit Polymorphs Pseudopolymorphs (including solvates) Complexation/solubilization Use of surfactants Use of cyclodextrins Drug dispersion in carriers Eutectic mixtures Solid dispersions (non-molecular) Solid solutions Chemical modifications Soluble prodrugs Salts 1.3 Solid Dispersions The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic matrix and a hydrophobic drug. The matrix can be either crystalline or amorphous. The drug can be dispersed molecularly, in amorphous particles (clusters) or in crystalline particles.7 Much of the research that has been reported on solid dispersion technologies involves drugs that are poorly water-soluble and highly permeable to biological membranes as with these drugs dissolution is the rate limiting step to absorption. Hence, the hypothesis has been that the rate of absorption in-vivo will be concurrently accelerated with an increase in the rate of drug dissolution. Therefore, solid dispersion technologies are particularly promising for improving the oral absorption and bioavailability of BCS Class II drugs. 1.3.1 Types of solid dispersions On the basis of release mechanisms and molecular arrangement in the matrix, solid dispersions are distinguished into following types9: A. Simple eutectic mixture: Eutectic mixture is prepared by rapid solidification of fused melts of two components that show a complete liquid miscibility with negligible solid-solid solubility. It involves loose atomic or molecular interaction and not on the formation of chemical bonds. When the eutectic mixture is exposed to gastrointestinal fluids, both the poorly soluble drug and the carrier may simultaneously crystallize out as a very small particles result in an increased the surface area and improved dissolution and absorption of the drug. B. Solid solution: A solid solution represents a homogenous one phase system, where the solid solution is dissolved in a solid solvent and the two components crystallize together. The solid solution achieves faster dissolution than a eutectic mixture because the drug particles in a solid solution are reduced to molecular size and dissolution of the drug takes place in the solid state prior to the exposure to the liquid medium. C. Glass solution: It is a homogenous glassy system in which a solute dissolves on glassy solvent results in increased dissolution and absorption of the drug. It is characterized by a transparency and brittleness below the glass forming temperature. Glass solution is a metastable and the strength of the chemical bonding is much less as compared to solid solution. Therefore, the release of the drug was found to be faster than a solid solution. D. Amorphous precipitations in crystalline carrier: An amorphous form of a drug produces faster dissolution rate. The drug may precipitate out in an amorphous form in a crystalline carrier from solid dispersions prepared by melting or solvent method. A strong interaction between the drug and carrier resulting in the formation of channels within the matrix seems to be a possible mechanism for improved dissolution of the drug. E. Compound or complex formation: The formation of a complex between the drug and the carrier may either decrease of increase the dissolution and the absorption rate of the drug. The formation of soluble complex with low association constant resulted in increased rate of dissolution and absorption. The enhancement in dissolution rate of the drug can be ascribed to An increasing solubility of the drug because of its amorphous state or small particle size (Kelvins law)9,10 An increased surface area available for drug dissolution because of the small size of the drug particles11,12 An improvement in wetting of the drug caused by the hydrophilic carrier13,14 1.3.2 Advantageous properties of solid dispersions Management of the drug release profile using solid dispersions is achieved by manipulation of the carrier and solid dispersion particle properties. Parameters such as carrier molecular weight and composition, drug crystallinity and particle porosity and wettability, when successfully controlled, can produce improvements in bioavailability.16 a. Particles with reduced particle size: Molecular dispersions, as solid dispersions, represent the last state on particle size reduction, and after carrier dissolution the drug is molecularly dispersed in the dissolution medium. Solid dispersions apply this principle to drug release by creating a mixture of a poorly water soluble drug and highly soluble  carriers. A high surface area is formed, resulting in an increased dissolution rate and consequently, improved bioavailability. b. Particles with improved wettability: Strong contribution to the enhancement of drug solubility is related to the drug wettability improvement in solid dispersions. It was observed that even carriers without any surface activity, such as urea improved drug wettability. Carriers with surface activity, such as cholic acid and bile salts, when used, can significantly increase the wettability properties of drugs. Moreover, carriers can influence the drug dissolution profile by direct dissolution or co-solvent effects. c. Particles with higher porosity: Particles in solid dispersions have been found to have a higher degree of porosity. The increase in porosity also depends on the carrier properties, for instance, solid dispersions containing linear polymers produce larger and more porous particles than those containing reticular polymers and, therefore, result in a higher dissolution rate. The increased porosity of solid dispersion particles also hastens the drug release profile. d. Drugs in amorphous state: Poorly water soluble crystalline drugs, when in the amorphous state tends to have higher solubility. The enhancement of drug release can usually be achieved using the drug in its amorphous state, because no energy is required to break up the crystal lattice during the dissolution process. 1.3.3. Carriers used in solid dispersions Many carriers of natural, semi-synthetic and synthetic types are being used which include natural carbohydrates, semi-synthetic and synthetic hydrophilic polymers. S.No:  1 Nature of carrier:  Sugars Name of the carrier:  Dextrose, sorbitol, sucrose, fructose,maltose,galactose, xylitol, mannitol S.No:  2 Nature of carrier:  Acids Name of the carrier:  Citric acid, tartaric acid and succinic acid S.No:  3 Nature of carrier:  Polymorphic materials Name of the carrier:  Polyvinyl pyrrolidone (PVP), polyethylene glycols, hydroxyl propylmethylcellulose (HPMC), guargum, xanthan gum, sodium alginate, methyl cellulose, pectin, hydroxyl ethyl cellulose (HEC), hydroxyl propyl cellulose (HPC) and dextrins. S.No:  4 Insoluble or enteric Nature of carrier:  polymer Name of the carrier:  Hydroxy propyl methyl cellulosepthalate, eudragit RL, eudragit L 100, eudragit S100, eudragit RS. S.No:  5 Nature of carrier:  Surfactants Name of the carrier:  Polyethylene stearate, poloxamer 188, tweens and spans. S.No:  6 Nature of carrier:  Miscellaneous Name of the carrier:  Nicotinic acid, succinamide, dextrans, gelatin, poly vinyl alcohol, urea, cyclodextrins, skimmed milk etc., Table 1.2 Various carriers used in solid dispersions 1.3.4. Preparation techniques of solid dispersions The following are the major processes for the preparation of solid dispersions. A. Solvent evaporation method: In this method, the physical mixture of two components is dissolved in a common solvent and followed by the evaporation of solvent. The advantages of this method are low temperature requirements for the preparation of dispersion and thermal decomposition of drugs and carriers can be prevented. The higher cost of production, incomplete removal of solvent, adverse effects of solvent on the chemical stability of the drug and selection of common solvent are the drawbacks of this method. B. Melting method (Fusion method): The physical mixture of drug and water- soluble carrier was heated to melt and the molten mixture was then cooled and solidified mass was crushed, pulverized and sieved. The melting point of a binary system depends on its composition and proper manipulation of drug carrier ratios. Decomposition should be avoided due to fusion time and the rate of cooling. C. Kneading method: The physical mixture of drug and carrier were triturated using small quantity of organic solvent and water mixture, usually alcohol and water (1:1v/v). The slurry is kneaded for 45 minutes and dried at 45 °C. The dried mass is pulverized and sieved through sieve no. 60 and the fraction was collected. The advantages of this method are low temperature requirements for solid dispersion preparation and usage of organic solvent is less. This method of preparation avoids thermal degradation of drug and employs less quantity of organic solvents. D. Melting solvent method: This method involves dissolving the drug in a suitable solvent and the incorporation of the solution directly into the molten carrier. This method possesses the advantages of both solvent and melting methods. E. Supercritical fluid methods: Supercritical fluid methods are mostly applied with carbon dioxide (CO2), which is used as either a solvent for drug and matrix or as an antisolvent. This technique consists of dissolving the drug and the carrier in a common solvent that is introduced into a particle formation vessel through a nozzle, simultaneously with CO2. When the solution is sprayed, the solvent is rapidly extracted by the SCF, resulting in the precipitation of solid dispersion particles on the walls and bottom of the vessel. This technique does not require the use of organic solvent and since CO2 is considered environmentally friendly, this technique is referred to as solvent free. This technique is known as Rapid Expansion of Supercritical Solution (RESS). F. Lyophilization/ Freeze Drying: This technique is an alternative to the solvent evaporation method. Here the drug and carrier are dissolved in common solvent, frozen and sublimed to obtain a lyophilized molecular dispersion. G. Melt agglomeration process: This technique is used to prepare solid dispersion where a binder acts as a carrier. The solid dispersion is prepared by heating binder, drug and excipient to a temperature above the melting point or spraying the dispersion of drug in the molten binder on the heated excipients using a high shear mixer. The effect of binder type, method preparation and particle size are the critical factors influencing the solid dispersion preparation by this method. These parameters results in various dissolution rates, mechanism of agglomerate formation and growth, agglomerate size and distribution. 1.3.5. Limitations of solid dispersion systems: Problems limiting the commercial application of solid dispersions are: Laborious and expensive method of preparation. Reproducibility of physico-chemical characteristics. Difficulty in incorporating into the formulation of dosage forms. Crystallization of the amorphous drug in the dispersion. Poor scale up of manufacturing process and physical and chemical stability of drug and the vehicle. 1.4 FDTs: Fast-disintegrating and fast-dissolving tablets are becoming popular as novel delivery systems for drug administration. They are more convenient for children, elderly patients, patients with swallowing difficulties, and in the absence of potable liquids. The most desirable formulation for use by the elderly is one that is easy to swallow easy to handle. Taking these requirements into consideration, attempts have been made to develop a fast-disintegrating tablet. Since such a tablet can disintegrate in only a small amount of water in the oral cavity, it is easy to take for any age patient, regardless of time or place. For example, it can be taken anywhere at anytime by anyone who do not have easy access to water. It is also easy to dose the aged, bedridden patients, or infants who have problems swallowing tablets and capsules. Recently, many companies have researched and developed various types of fast-disintegrating dosage forms.18 These tablets display a fast and spontaneous de-aggregation in the mouth, soon after the contact with saliva, though they can be handled or extracted from the package without alteration. The active agent can thus rapidly dissolve in the saliva and be absorbed through whatever membrane it encounters, during deglutition, unless it is protected from pre-gastric absorption. To fulfill these requirements, tablets must be highly porous, incorporating hydrophilic excipients, able to rapidly absorb water for a rapid deaggregation of the matrix. Different technological techniques, such as freeze drying or molding or direct compression are currently employed to prepare the formulations of this type present on the pharmaceutical market. 1.4.1 Advantages of Fast Disintegrating Drug Delivery System (FDDS) 19,20 Ease of administration to patients who refuse to swallow a tablet, such as pediatric and geriatric patients, mentally ill, disabled and uncooperative. Convenience of administration and accurate dosing as compared to liquids. No need of water to swallow the dosage form, which is highly convenient feature for patients who are traveling and do not have immediate access to water. Good mouth feel property of FDDS helps to change the basic view of medication as bitter pill, particularly for pediatric patients. Ability to provide the advantages of liquid medication in the form of solid preparation. Rapid dissolution of drug and absorption, which may produce rapid onset of action. Some drugs are absorbed from the mouth, pharynx and oesophagus as the saliva passes down into the stomach; in such cases bioavailability of drugs is increased. Pregastric absorption can result in improved bioavailability and as a result of reduced dosage, improved clinical performance through a reduction of unwanted effects. 1.4.2 Approaches for fast disintegrating tablets A. Patented technologies Currently, four fast-dissolving/disintegrating technologies have reached the U.S. market: Zydis (R.P. Scherer, Inc.) WOWTAB (Yamanouchi Pharma Technologies, Inc.) OraSolv (Cima Labs, Inc.) DuraSolv (Cima Labs, Inc.) B. Three others are available outside the U.S. Flash Dose (Fuisz Technologies, Ltd.), Flash tab (Prographarm Group), OraQuick (KV Pharmaceutical Co., Inc.) Nanocrystal Technology C. Conventional technologies Freeze -drying or lyophilization Tablet Molding Direct compression Spray drying Sublimation Mass extrusion Direct compression It is the easiest way to manufacture tablets. Conventional equipment, commonly available excipients and a limited number of processing steps are involved in direct compression. Also high doses can be accommodated and final weight of the tablet can easily exceed that of other production methods. Directly compressed tablets disintegration and solubilization depends on the single or combined action of disintegrates, water soluble excipients and effervescent agent. Disintegrate efficacy is strongly affected by tablet size and hardness. Large and hard tablets have a disintegration time more than that usually required. As consequences, products with optimal disintegration properties often have medium to small size and /or high friability and low hardness. Breakage of tablet edges during handling and tablet rupture during the opening of blister, all results from insufficient physical resistance. Disintegrants have a major role in the disintegration and dissolution process of mouth dissolving Tablets made by direct compression. To ensure a high disintegration rate, choice of suitable type and an optimal amount of disintegrant is important. Other formulation components such as water soluble excipients or effervescent agents can further enhance dissolution or disintegration properties. But the main drawback of using effervescent excipients is their highly hygroscopic nature. The understanding of disintegrant properties and their effect on formulation has advanced during the last few years, particularly regarding so called superdisintegrants. Disintegration efficiency is based on a force equivalent concept, which is the combined measurement of swelling force development and amount of water absorption. Force equivalent expresses the capability of disintegrant to transform absorbed water into swelling force. The optimization of tablet disintegration was defined by means of disintegrant critical concentration. Below this concentration, the tablet disintegration time is inversely proportional to disintegrate concentration and above that disintegration time remains approximately constant or even increases. The simultaneous presence of disintegrate with a high swelling force called disintegrating agent and substances with low swelling force ( starch, cellulose and direct compression sugar) defined as, swelling agent was claimed to be a key factor for the rapid disintegration of the tablet, which also offers physical resistance. 1.4.3 Mechanism of tablet disintegration and water absorption When mouth dissolving tablets placed in the mouth, upon contact with saliva the tablet disintegrates or dissolve instantaneously. The mechanisms involved in the tablet disintegration mechanisms are Swelling Wicking (capillary) Deformation Particle repulsive forces Chemical reaction (acid base reaction) a. Swelling Not all disintegrates swell in contact with water swelling is believed to be a mechanism in which; certain disintegrating agents (like starch) impart their disintegrating effect. By swelling in contact with water, the adhesiveness of other ingredients in a tablet is overcome causing the tablet to disintegrate. b. Wicking (porosity and capillary action) Effective disintegrants that do not swell are believed to impart their disintegrating action through porosity and capillary action. Tablets porosity provides a way for the penetration of fluid into tablets. The disintegrants particles (with cohesiveness and compressibility) themselves act to enhance porosity and provide these capillaries into the tablets. Liquid is drawn up or wicked into these ways by capillary action and rupture the inter-particulate bonds causing the tablet to break into small parts. c. Deformation Starch grains are generally thought to be elastic in nature that is the grains that are deformed under pressure will return to their original shape when that pressure is removed. But, with the compression forces involved in tabletting, these grains are permanently deformed and are said to be energy rich with these energies being released upon exposure to water, that is the ability for starch to swell is higher in energy rich starch grains than in starch grains that have not been deformed under pressure. It is believed that no single mechanism is responsible for the action of most disintegrants. But rather, it is more likely the results of interrelationships between these major mechanisms. d. Due to disintegrating particle/particle repulsive forces: Another mechanism of disintegration attempts to explain the swelling of tablets made with non-swellable disintegrants. Guyot-Hermann has proposed a particle repulsion theory based on the observation that nonswelling particle also causes disintegration of tablets. The electric repulsive forces between particles are the mechanism of disintegration and water is required for it. Researchers found that repulsion is secondary to wicking. e. Chemical reaction (acid base reaction) Disintegration of tablet included with citric acid and tartaric acid along with the sodium bicarbonate, sodium carbonate, potassium carbonate; these react in contact with water to liberate carbon dioxide that disrupts the tablet. Name of the Product:  Imodium Lingual Active Ingredients:  Loperamide hydrochloride Dose:  2 mg Name of the Product:  Pepcidin Rapitab Active Ingredients:  Famotidine Dose:  20mg and 40 mg Name of the Product:  Mosid MT Active Ingredients:  Mosapride citrate. Dose:  2.5mg and 5mg Name of the Product:  Calritin Reditabs Active Ingredients:  Loratadine Dose:  10 mg Name of the Product:  Nimulid MD Active Ingredients:  Nimesulide Dose:  50mg and 100mg Name of the Product:  Zyrof Meltab Active Ingredients:  Rofecoxib Dose:  50 mg Name of the Product:  Feldene Melt Active Ingredients:  Piroxicam Dose:  10mg and 20 mg Name of the Product:  Maxalt-MLT Active Ingredients:  Rizatriptan Dose:  5mg and 10 mg Name of the Product:  Pepcid RPD Active Ingredients:  Famotidine Dose:  20mg and 40 mg Name of the Product:  Zyprexa Zydis Active Ingredients:  Olanzapine Dose:  5mg, 10mg, 15mg and 20 mg Name of the Product:  Zofran ODT Active Ingredients:  Ondansetron Dose:  4 mg and 8 mg Name of the Product:  Remeron Soltab Active Ingredients:  Mirtazepine Dose:  15mg, 30mg and 45 mg Name of the Product:  NuLev Active Ingredients:  Hyoscyamine sulfate Dose:  0.125 mg Table 1.3 Marketed fast disintegrating tablets Piroxicam, a non-steroidal anti inflammatory agent, belonging to BCS class II is widely used as a first line drug in the symptomatic relief of rheumatoid arthritis and osteoarthritis. Its low aqueous solubility has to be overcome through formulation strategies. Skimmed milk can be used as a drug carrier as it is inexpensive, easily available, biodegradable, and does not exhibit toxicity problems as experienced with PEG and PVP.24-26 Polymers  as  carriers  also  have  limitations  in  enhancing  Ã‚  the  Ã‚  solubility  of poorly  soluble drugs  due to  their  high viscosity. So the use of skimmed milk in the formulation of the SD of the drugs with limited aqueous solubility may be a potential and cost effective way to overcome the problem.27 Skimmed milk is a colloidal suspension of casein micelles, globular proteins and lipoprotein particles. The principal casein fractions are a-s1, a-s2, b-casein and k-casein. b-casein is amphiphilic and acts as a detergent molecule with surfactant property. The milk also contains whey proteins with principle fractions of the b-lacto globulin, a-lactalbumin, bovine serum albumin and immunoglobulins. These molecules were found to be surface active with a superior solubility than caseins.28 Aminoacids have been suggested either as additives in peroral application or in the form of aminoacid salts to reduce gastrointestinal disorders arising due to piroxicam like NSAIDs. The surface active agents and amino acid content are expected to be the reason for increased permeation of the drug from the solid dispersion.29,30

Archetype of Hero in the Film Amazing Grace :: essays research papers

During the 18th century millions of men, women and children were taken from their homes in Africa and sold into slavery. Few survived the slave ships, and even fewer lived through their slave labors. Few people thought the slave trade was wrong, and to find one who had the courage to stand-up against it seemed impossible. Humanity needed a hero, someone who could establish equality. The movie Amazing Grace tells the account of an Englishman who gave his health and youth to end the slave trade. Like heroes of history and literature, William Wilberforce's story followed the archetype of a traditional hero. William Wilberforce was an example of a common mortal hero. He was a normal, completely realistic person, in that he stumbled many times and often emphasized his humanity by saying, ?Am I not a man After years of work without success he felt he had failed, but he still pressed forward. He possessed no extraordinary power or skill, but he rose to the occasion and changed the world. Not only was William one of the few who was disgusted by the slave trade, he was also one of the select few who had the courage to stand up against it. Someone once said, ?Courage does not consist in feeling no fear, but in conquering fear. He is the hero who seeing the lion on either side goes straight on, because there his duty lies.? William saw the lions?many of them, nevertheless he continued on because he knew it was his duty. William Wilberforce was an ordinary man, but he was able to overcome fear and be a hero. However, he would not have been able to do it without the help of many friends. Loyal companions have played a large role in many hero stories, and the story of William Wilberforce is not different. William Pitt, the Prime Minister, was William Wilberforce?s best friend. He was able to keep Wilberforce in good standing and also assisted in the eventual success of his bill which banned the slave trade. William Pitt also encouraged him to keep trying. After a race across the lawn William Pitt said, ?Why is it that you only feel the thorns in your feet when you stop running? You must keep going, fast.? William Pitt was one of the main reasons for his friend?s success. Without him, William Wilberforce would have quit, and even if he had continued trying he would never have been able to pass his bill.

Gambling †the economy, household and society Essay

The subject of gambling has been a hot subject of debate amongst politicians for many years. The concept of people waging something of value for something not guaranteed is something that baffles many non-gamblers. Long before Christopher Columbus discovered North America gambling was practiced quite often amongst Native Americans (Sheppard, 2012). In fact one can trace the origins of gambling even farther back into biblical times. This is evident by the biblical verses in the Bible about the dangers of gambling and why individuals should not gamble (King James Bible Online, 2013). According to the Alberta Gambling Research Institute, â€Å"The history of gambling in Canada is inextricably linked to the Canadian Criminal Code, which in 1892 declared a complete ban on most gambling activities with the exception of horse racing†(Stevens, 2005). Over the next 77 years the Criminal Code will make many exceptions for smaller-scaled gambling, such as betting on horse races or gambling at ‘summer fair midways’ (Stevens, 2005). Eventually an amendment was made so that federal-run lotteries can be used to help fund meaningful activities, such as the 1976 Montreal Olympics. In more modern times the restrictions for gambling is much more relaxed. â€Å"Ticket lotteries, horse racing, and charitable gaming (including bingo) are currently legal in all ten provinces, Yukon Territory, Northwest Territories, and Nunavut Territory† (Stevens, 2005). Casino-style gambling is also allowed in most provinces and in all territories, as well as slot machines (Stevens, 2005). The focus of this argumentative essay will be why gambling is bad to Canadian society, and should continue being outlawed. Although one can argue that there are benefits to gambling, but this essay will look to dismiss such arguments and focus on the negative aspects of gambling. In order to go about this efficiently, this essay will look at gambling from an economical, moral and societal viewpoint. From an economic standpoint it is quite easy for one to say that gambling would improve the economy greatly. After all there are many who love nothing more than to poor their entire wallets into a machine, hoping to strike gold, not to mention that casino gambling, the highest grossing form of gambling, is the form of gambling that appeals to individuals the most (McLean, 2013). As I had mentioned previously, federal-run lotteries also helped to fun the 1976 Montreal Olympics. With all this said, gambling actually does not improve a country financially, and casinos will specifically be targeted to prove this point. Detroit is a city with 3 casinos, built with the intent of bringing in revenue to a city needing financial stability and quick income. Now, after over a decade of dumping hundreds of millions of dollars from taxes on the casinos, the city has more or less nothing to show for it. In fact, Detroit has become so financially strapped that the casinos no longer pays for anything ‘extra’, such a museum or an Olympic competition; Detroit museums instead pays for the garbage services and the electricity bill to keep the lights on the streets working (Henderson, 2012). Now one can argue that not all cities with casinos end up in financial trouble, with Las Vegas being a common example of this. The only difference with this argument is that Las Vegas has attractions that would flourish even without casinos (Henderson, 2012). In fact, the city of Toronto just recently came to its senses and decided against building a casino in the downtown area, saving the city millions of dollars that could better-used in other places (Baggage, 2013). There are many financial repercussions that come with having a casino, and although it is a wonderful argument it is not the entire focus of this essay. To touch upon how morally damaging a fact from an earlier paragraph will have to be drawn upon. In the Bible there are many passages that speak of how terrible gambling is. Now, there are many people who do not associate with the bible, and many of the historical details are debatable. With this being said, it is a fact that for many years Canada was primarily Catholic (Wallace, 1948), meaning it is religion played a major role in shaping Canadian society. With that said, one of the religious books Catholics use for moral guidelines is the Bible (Catholic Evidence Guild, 1921). Therefore, it is also indisputable that the Bible contains morals that are also right, as evident from Canadian society being sustainable and without war. Now the bible does not go into great detail as to why gambling is wrong, but one can look at today’s society and make a great case. In Canadian society there is a steady increase of problem gamblers (Problem Gambling Institute of Ontario, 2013). This problem has become a serious issue, and is, reflected in the industry growing to keep up with the demands (Koprowski, 2007). These problem gamblers are somebodies mother, father, son or daughter, which can and will affect a household in many different ways. Besides the obvious loss of money, belongings and property, there are many emotional effects as well. Many friendships are destroyed due to unpaid debts, partners do not want close contact with the person who has hurt them (Problem Gambling Institute of Ontario, 2013), and in the end the addict is left without affection in isolation. From a psychological perspective, the individual is left in isolation due to either being shunned or being too ashamed to be around others. Naturally there are extreme cases of those committing suicide after being driven to seclusion and gamblers are no exception; â€Å"1 in 5 compulsive gamblers attempts suicide and two-thirds have thought about committing suicide† (Gaultiere, 2011). From a sociological and anthropological perspective, this is proof of the family system deteriorating. In conclusion gambling is bad for Canada not only financially but socially speaking as well. Although it is unrealistic to want all forms of gambling to be illegal, there should be some form of restrictions on those who spend too much time at the casino, or something along those lines. Works Cited Baggage, M. Toronto rejects controversial downtown casino. http://www. ottawacitizen. com/news/Toronto+rejects+controversial+downtown+casino/8416596/story. html, 2013. Catholic Evidence Guild. Catholics and the Bible.http://catholiceducation. org/articles/religion/re0032. html, 1921. Gaultiere, B. Don’t Bet On It: Help For Compulsive Gamblers. http://www. newhopenow. org/notes/archive/dont_bet_on_it. html, 2011. Koprowski, G. Gambling Growing in Canada. http://www. onlinecasinocrawler. com/blog_gambling-growing-in-canada. php, 2007. McLean, J. Gambling In Canada. http://gocanada. about. com/od/thebestofcanada/tp/Gambling-In-Canada. htm, 2013. Problem Gambling Institute of Ontario. The Effects of Gambling on Families. http://www. problemgambling. ca/EN/GettingHelp/Pages/TheEffectsOfGambling. aspx, 2013. Sheppard, R. Gambling.http://www. thecanadianencyclopedia. com/articles/gambling http://www. kingjamesbibleonline. org/Jonah-1-7/, 2012. Stephen, H. Detroit has little to show for its casino revenue. http://www. freep. com/article/20120513/COL33/205130480/. Stephen-Henderson-Detroit-has-little-to-show-for-its-casino-revenue, 2012. Stevens, R. Legalized Gambling In Canada. http://www. abgamblinginstitute. ualberta. ca/en/LibraryResources/Bibliographies/LegalizedGamblinginCanada. aspx, 2005. Wallace, W. Religious History of Canada. http://faculty. marianopolis. edu/c. belanger/quebechistory/encyclopedia/CanadaReligiousHistory_000. htm, 1948.

Death Penalty in South Africa Essay

Witbank was established in 1890 and early attempts to exploit the coal deposits failed until the railway from Pretoria reached the area in 1894. It was proclaimed a town in 1903 and became a municipality in 1914. Despite attempts by governing bodies to establish the use of the name, eMalahleni, for the city as well as for the district, locals still tend to call the city by its original name. Similarly to the anglicised pronunciation of Johannesburg, English-speaking residents pronounce the name as â€Å"wit†¢bank† and not as â€Å"vit†¢bunk† as in the original Afrikaans pronunciation, nor as â€Å"vit†¢bank† as English-speaking visitors are prone to say. There are many stories about the city and its origination but the top story would be the arrival of Winston Churchill at the nearby Transvaal and Delagoa Bay Colliery during his escape from Boer imprisonment in Pretoria, on his way to Delagoa Bay (later Lourenco Marques, and then Maputo, in Mozambique). Some local residents, loyal to the Crown, assisted him in hiding and making the final leg of his escape, thus gaining Witbank the consequent credit once the details of these events could be made known. The town has grown since then from a farming community into a business destination where companies such as Anglo American, BHP Billiton, Evraz, Eskom, Exxaro, Joy, Komatsu, the Renova Group, SAB Miller, SAMANCOR, Shanduka Beverages, Xstrata and Zenith Inc amongst many others have found substantial returns on their investments. Witbank is located along the railway line linking Pretoria to Maputo and for many years served as the transport gateway to the Mozambiquean port. In recent years, this line has been under frequent threat of collapse due to underground coal fires in disused mines in the area. Two national highways, the N4 from Pretoria and the N12 from Johannesburg, converge at Witbank and then continue to Komatipoort, on the border of Mozambique. Together, these routes form the Maputo Corridor, a strategically important alternative to the South African ports of Richards Bay and Durban on the Indian Ocean shores of the country. Witbank is in a coal mining area with more than 22 collieries in the municipal radius. There are a number of power stations (such as the Duvha Power Station), as well as a steel mill (Evraz Highveld Steel and Vanadium Limited) nearby which all require coal. The farm land surrounding Witbank is fast being bought by investors, coal mining companies and real estate developers to accommodate the rapid growth of the city which is good for local businesses and residents. Likewise, the sustained growth of the commercial areas and suburbs has presented significant challenges to the municipal government. Potable water supplies, sewage treatment, electricity distribution, refuse collection and road maintenance are particularly affected, arousing sustained ire amongst the local residents. Relatively high summer rainfall since 2008 has caused significant damage to municipal roads, creating large numbers of potholes and leaving large amounts of debris on the road surfaces. As Witbank is en route to travellers from the Gauteng province to the Kruger National Park, attempts have been made to capture some of the potential tourist spend. Apart from a few hotels, there are many guest houses. These vary from the utilitarian to the luxurious, and also cater for many of the business travellers visiting Witbank as well as those travelling to Nelspruit, Swaziland and Mozambique. A casino complex is accessible within a few hundred meters from the N4 highway, providing two hotels, cinemas, ten-pin bowling and restaurants as well as the traditional gambling facilities. The Highveld Mall is built immediately next to the casino and is a retail hub for locals as well as for many residents of towns in the vicinity. Mpumalanga i/? m? pu? m l / (name changed from Eastern Transvaal on 24 August 1995), is a province of South Africa. The name means east or literally â€Å"the place where the sun rises† in Swazi, Xhosa, Ndebele and Zulu. Mpumalanga lies in eastern South Africa, north of KwaZulu-Natal and bordering Swaziland and Mozambique. It constitutes 6. 5% of South Africa’s land area. In the north it borders on Limpopo, to the west Gauteng, to the southwest the Free State and to the south KwaZulu-Natal. The capital is Nelspruit (recently renamed to Mbombela). Prior to 1994, Mpumalanga was part of Transvaal Province. Mpumalanga Travel Guide / Formerly known as the Eastern Transvaal, Mpumalanga is one of South Africa’s top tourist destinations. People are drawn to Mpumalanga by the magnificent scenery, by the fauna and flora and by the saga of the 1870s gold rush era and a wealth of fascinating tribal legends. Aptly know as â€Å"Paradise Country†, few regions in the world can match the extraordinary beauty of the Mpumalanga Lowveld and escarpment. Mountains, panoramic passes, valleys, rivers, waterfalls and forests characterise the landscape. This is also Big Game Country, the setting for dozens of sanctuaries teeming with wildlife and birds. Among them, the Kruger National Park is world renowned, as are several of the luxurious private reserves on its western boundary. The entire Mpumalanga area offers exceptional opportunities for bird-watching, hiking, horse-riding and fishing. Streams once panned for gold have become the haunts of eager anglers and lazy trout. Steeped in the history of pioneers, hunters and fortune seekers, fascinating gold rush towns abound. Barberton and Pilgrim’s Rest are among the most famous. A special, additional dimension occurs in the Middleveld region which is inhabited by Ndebele people, notable for their traditional costumes and attractively decorated houses.